A pandemic can be a pathological occurrence rapidly spreading and affecting humans and animals worldwide.  The World Health Organization (WHO), an international agency, closely and critically monitors various infectious agents that can induce morbidities and mortalities in humans and animals.  Healthcare professionals in the WHO observe epidemiological profile, vulnerability, adaptability, and virulence, to design proper healthcare outcomes to improve the quality of life.  Thus, one integral approach is to design novel compounds to prevent the growth of infectious pathogens.  Therefore, this study synthesized and characterized the novel Thiazolidinone Derivatives (2-imino-5-phenyl-4-thiazolidinone). Furthermore, the antimicrobial pharmacodynamic actions were evaluated. 

Synthesis: 2-imino-5-phenyl-4-thiazolidinone condensed with substituted aromatic aldehydes (o-nitrobenzaldehyde, m-nitrobenzaldehyde, and p-nitrobenzaldehyde) in the presence of ethanol, Glacial acetic acid, and sodium acetate to form corresponding substituted 2-imino-5-phenyl-4-thiazolidinone derivatives.

Characterization:

The melting point was checked in an open capillary tube using a melting point determination apparatus. The purity of the synthesized compounds was checked by TLC using Silica gel-G as the stationary phase and Chloroform/Methanol (9:1) as the mobile phase.  The molecular property and bioactivity score of the synthesized compounds were calculated by using molinspiration.  Furthermore, FT-IR and 1H-NMR, 13C-NMR spectral data were also obtained.

Evaluation of antibacterial and antifungal activities:

All synthesized novel Schiff base substituted Thiazolidinone compounds were tested against Gram-positive organisms (Staphylococcus aureus), Bacillus, and Gram-negative microorganisms (Escherichia coli, Salmonella), and fungus (Candida albicans)

Results:

FT-IR and 1H-NMR, 13C-NMR characterized and validated the synthesized compounds. The novel thiazolidinone derivatives exhibited moderate to potent antibacterial and antifungal activities.

Key words:Thiazolidinone Derivatives, Schiff Base, Antimicrobial Pharmacodynamic actions