Development of an Aesthetic and Effective formulation with Natural Vinca bioactives to cure various canine dermal pathologies

Primary Author: Kiruba Mohandoss

Additional Authors: Tanmayee Paladugu, Muralikrishnan Dhanasekaran

1. Sri Ramachandra Faculty of Pharmacy, Chennai- 600116, Tamil Nadu, India
2. Sri Ramachandra Institute of Higher Education and Research, Chennai - 600 116, Tamil Nadu, India
3. Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA, 36848

Introduction In recent years, the number of dermatological pathologies and diseases such as dermatitis, skin sores, lesions, and rashes in pet animals (canines, felines, and birds) has drastically increased. If untreated, it can increase the risk for numerous disease conditions such as chronic inflammatory disorders, infections, and oncogenesis. Therefore, there is an imminent requirement for potent synthetic and natural bioactives to prevent and treat this perilous condition. Vinca minor contains potent natural bioactives such as Vincamine (Vinca alkaloid similar to Vinblastine) and Vincristine ^[1].  Vinblastine and Vincristine exert cytotoxic properties by inhibiting cell division and growth. They are already in therapeutic use to treat various tumors and cancers (Breast cancer, Uterine cancer, Leukaemia, and Hodgkin's disease) ^[2]. However, very few research studies have investigated the effect of Vincamine in preventing and treating canine dermatological pathologies and diseases.  

However, this potent natural bioactive modulates inflammation and possesses antimicrobial actions. Consequently, the current goal is to prepare a novel aesthetic and safe natural bioactive formulation that can heal wounds effectively and reduce dermal damage.

Aim: The current research aims to assess the efficacy of Vinca alkaloids, primarily Vincamine, to treat dermal ailments in animals (Especially canines). In addition, the therapeutic effect of Vincamine in combination with Vinblastine and Vincristine will be investigated.

Objective: To formulate an aesthetically safe novel formulation (spray) with vinca alkaloids and test its therapeutic efficacy against canine dermal disorders.

Methodology

1.  Prepare a spray Formulation with Vinca alkaloids

2.  Assess the antioxidant activity and antibacterial study

3.  Establish the wound-healing activity

Outcome:

The novel Vinca-based spray formulation can prevent and protect against dermal wounds or diseases. Vincamine combined with Vinblastine and Vincristine has exhibited anti-neoplastic effects for treating various types of cancer.

Conclusion:

This specific alkaloid (Vincamine) combined with Vinblastine and Vincristine can exert a synergistic pharmacodynamic action to treat a variety of canine dermal pathologies ranging from wound healing to skin cancer.

Reference

1.        Dhyani P, Quispe C, Sharma E, Bahukhandi A, Sati P, Attri DC, et al. nticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int 2022;22(1):206.

2.        Noureddine Bribi. Pharmacological activity of Alkaloids: A Review. Asian J Bot 2018;1(April):1–6.