DESIGN AND EVALUATION OF NIOSOME EMBEDDED TRANSDERMAL PATCH OF NIFEDIPINE 

Primary Author: K. Reeta Vijaya Rani¹

 Additional Authors:  Kiruba Mohandoss², Mullaicharam Bhupathyraaj³,               Muralikrishnan Dhanasekaran⁴, S. Jemimah⁵

 1. Department of Pharmaceutics, Surya School of Pharmacy, Surya Group of Institutions, Vikravandi, Villupuram – 605 652, Tamilnadu, India.

2. Sri Ramachandra Institute of Higher Education and Research, Chennai - 600 116, Tamil Nadu, India

3. College of Pharmacy, National University of Science and Technology, Muscat, Oman.

4. Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn

University, Auburn, AL, 36849, USA.

5. PG & Research Department of Chemistry, Bishop Heber College, Trichy, Tamil Nadu, India.

ABSTRACT

AIM: To design and evaluate the niosome embedded adhesive transdermal patch of nifedipine.

METHOD:  Niosomes containing nifedipine were prepared by thin film hydration technique with different ratios of surfactants - span (20, 40, 60, 80) and cholesterol.  The nifedipine niosome-loaded transdermal patch was prepared by solvent evaporation technique. The niosome formulation containing the drug was converted to a carrier drug-in-adhesive patch using Acrylic vinyl acetate. Various formulation parameters and excipients were optimized to get a thin, translucent, smooth, stable, and highly permeable character patch.

 RESULTS & DISCUSSION:

ü The entrapment efficiency of nifedipine niosomes in NF6 containing span60: cholesterol in the ratio of 2:1 was found to be 78.1%. It showed the maximum percent of drug entrapment compared to all other formulations and hence this formulation was selected for further studies.

ü All the batches are uniform in appearance and showed no visible cracks.

ü The use of niosome drug-in-adhesive patch combination successfully sustains the release rate of nifedipine.  

ü The release kinetics showed the best formulation TF2 follows zero-order diffused controlled release and follows Non-Fickian diffused controlled mechanism (Korsmeyer-Peppas). This study found high encapsulation efficiency and good sustained release over 12 hours presenting promising characteristics as compared to other formulations.

CONCLUSION: From the results it may be concluded that which can be tailored to produce a suitable single dose administration per day.  The stability studies also proved that transdermal formulation is stable during storage at 40^◦C ± 2^◦C RH 70% ± 5%. The present project work has achieved the objective of formulating effective transdermal nifedipine delivery systems with the novel design of niosome - drug-in -adhesive patches.

KEYWORDS: Niosome - drug-in - adhesive patches, Niosome embedded transdermal patch, Nifedipine