Beta-adrenergic antagonists are the first line of therapy against tremors.  Thus, the existing literature clearly depicts the required pharmacokinetic and pharmacodynamic parameters for these drugs to act in the central nervous system (CNS) and exert neuroprotection.  However, there are very few studies that have elucidated the dopaminergic neuroprotective effects of sympatholytics (Beta-adrenergic antagonists).Dopaminergic neurodegeneration occurs mainly due to oxidative stress, inflammation, and apoptosis. In the present study, Nebivolol, a cardioselective Beta-adrenergic antagonist was investigated for its dopaminergic neuroprotective action.  1-Methyl, 4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) was used as the dopaminergic neurotoxin. Nebivolol exerted antioxidant, anti-inflammatory,inhibited apoptosis and protected against the neurotoxic effects of MPTP. 

Key Words: Dopaminergic neurotoxicity, MPTP, Nebivolol, Dopamine