Abstract

Chronic Traumatic Encephalitis (CTE) is a relatively unknown disease which stems from repeated closed head injuries. Currently, the only diagnosis of the disease is an observation of an abnormally high concentration of neurofibrillary tangles, which is concluded during a post-mortem. This review discusses the diagnosis of the disease in-vivo and its anatomical effects using technological advancement. Further, there are many postulated theories of the mechanism which will be explored in this paper. The injuries do not affect everyone equally as genetic and environmental factors serve as mediators to the disease. Lastly, the review investigates a few pharmaceutical facets to slow down the progression of CTE and minimize its effects. Though it affects a select group of the world’s population, examination into CTE may not only give us a better understanding of the brain and brain-related trauma but also unveil the secrets of many neurological diseases such as Parkinson’s and Alzheimer’s dementia.