Cannabis usage has garnered a lot of interest as a possible therapeutic target for cancer and cancer-related ailments. It has been linked to neurological problems. Cancer chemotherapy-induced nausea and vomiting management and appetite stimulation are physiological functions that cannabinoids perform in our bodies that are the primary subjects of interest as a possible cancer treatment. In systematically reviewing 792 articles, our goal was to characterize possible therapeutic cannabis medication interactions as well as the cannabis safety profile since pharmacokinetic and pharmacodynamic interactions might occur when other drugs are taken together. The half-life of cannabidiol was reported to vary among the different methods of administration of cannabis. Cannabis is found to have a wide range of effects in the body, specifically in the cardiovascular, respiratory, and neurological organ systems. Pharmacodynamic activity on specific brain receptors caused impairments of psychomotor performance related to the dosage received with consequences for driving a vehicle, piloting an airplane, and academic performance. Other components of cannabis smoke convey respiratory and cardiovascular health risks analogous to those of tobacco smoke. Prescription medication interactions and drug-to-drug reactions to cannabis have been documented, according to newly released research. Cannabis is often well-tolerated, however, bidirectional effects by enzyme metabolizing medications cannot be excluded. Cannabis users' answers to different drugs should be carefully scrutinized to guarantee their well-being. This is particularly true for elderly people with various medical problems. If a more balanced approach is taken, legalizing the use of cannabis for medicinal purposes will be much more beneficial.