Abstract: 

The endocannabinoid system was discovered and named because of the extended historical use of Cannabis throughout history for fiber, medicinal, and psychoactive reasons by many different cultures. The major biosynthetic pathways of the endocannabinoid system produce anandamide and 2-arachidonoylglycerol. The endocannabinoid system acts in a rectangular manner. From there on, the endocannabinoid system became seriously studied and researched in multiple scientific fields. The current study investigated novel and innovative neuropharmacological approaches to regulate cannabinoid neurotransmission. The molecular signaling systems in neuroscience have become increasingly important to understand and perform research to discover the physiological and pathologic roles of the endocannabinoid system. The worldwide in-depth research in this field has, in a brief period, created effective and selective drugs targeting the endocannabinoid system that have provided innovative ways to potentially treat significant diseases such as cancer, pain, and neurodegenerative diseases, anxiety, and addiction. This approach can be a new initiation for the modern age that learns from the ancient use of Cannabis as a therapeutic approach.

Primary Author: Dhingra, Jahnavi 

Additional Authors: Bowen Dylan; Ramesh Sindhu; Deruiter Jack; Govindarajulu Manoj; Pathak Suhrud; Moore Timothy; Dhanasekaran MuraliKrishnan.