The most common symptoms of SARS-CoV-2 are predominantly related to the pulmonary system/respiratory tract, however, there are several symptoms related to the nervous system.  The SARS-CoV-2 mediated CNS symptoms include anosmia, dysgeusia, myasthenia, vertigo, restlessness, euphoria, convulsions, depression, anxiety, and stroke.  However, the lethal mechanisms/pathways associated with the SARS-CoV-2-induced neurotoxic insults are unknown.  Thus, there is an immediate need to elucidate the neurotoxic mechanisms and neuronal pathways leading to irreversible neurodegeneration.  If the neurotoxic insults are not prevented or treated suitably, it will drastically increase the risk of several neurodegenerative disorders.  Hence, there is an impending and urgent requirement to elucidate the neurotoxic mechanisms and neuronal pathways to prevent/treat the neurological insults associated with SARS-CoV-2-induced neurotoxicity.  Relevant search terms contributing to the study objective were used across electronic platforms such as PubMed, Scopus, and Google Scholar, through June 2022 to establish the neurotoxicity associated with SARS-CoV-2-indued neurological insults. The current putative scientific neurotoxic mechanisms associated with an angiotensin-converting enzyme 2-mediated generation and infiltration of prooxidants, and pro-inflammatory cytokines from the periphery and crossing the blood-brain barrier to affect the neurons and glial cells in the central nervous system.  Furthermore, this research analysis will recommend several innovative antioxidants to prevent and counteract the neuroinflammation and oxidative stress induced by SARS-CoV-2.