While modern medicine primarily uses synthetic drugs, the bioactive components are derivatives of natural botanicals. For thousands of years, these botanicals, also called herbal medicine, has been used to treat a multitude of chronic and acute conditions. One particularly powerful botanical is Centella asiatica, also known as gotu kola in Sinhala,  mandukaparni in Sanskrit,  Kodokan in Malayalam,  pegaga in  Malaysia, tsubokusa in Japan,  tungchia or luei gong gen in China. Both odorless and tasteless, C. asiatica has been shown curative properties that significantly affect the central and peripheral nervous system. In this review, we have combed through the current literature around C. asiatica to create a significant overview of its prophylactic and pharmacodynamic effects. Our research suggests that in regards to its prophylactic effects, C. asiatica can be considered a strong antioxidant agent enhancing the Nrf2 response pathway. In regards to its pharmacodynamic attributes, C. asiatica can carry neurological, ocular, cardiovascular, respiratory, gastrointestinal, immunological, muscular, renal, and reproductive effects. For example, antidepressant effects, cardioprotective, and fertility are some of the few areas of concern that C. asiatica can address. Western medicine has often been seen as the gold standard of medical care, with Eastern and Ayurvedic medicine being cast off as folk treatments. It is our hope that through this review, C. asiatica can be brought into the light as an effective and alternative treatment strategy for healthcare provides with patients wanting more natural options.