Background Literature: The current globally prevalent and scientifically acknowledged concept associated with drug discovery is the mode and pattern of designing specific target-based (receptor, enzyme, pumps, ion-channels, & nucleic acid) drugs (molecules).  These novel target-based drugs (molecules) are expected to exert a potent pharmacodynamic effect through appropriate pharmacokinetic parameters, with minimal adverse drug reactions and without any hypersensitivity reaction. However, numerous pharmacologically active drugs (molecules) exert their pharmacodynamic effect via modulation of several drug targets (“proteins = enzyme, receptors, pumps” or “nucleic acid”) rather than single drug target. This scientific innovation and development, in sequence, has altered the hypothesis from a “specific target binding individual-drug based theory” to a “comprehensive network-based (several-component based) drug target for prophylactic, therapeutic, and restorative medicinal approaches” for animal and human healthcare. Thus, network pharmacology is more valuable and successful for validating a “Drug-Protein/Gene-pathology” network and furthermore to unveil the mechanism of action of drugs associated with treatment of a pathological condition. Thus, this contemporary scientific methodology creates an exceptionally robust technique for assessing the of pharmacodynamic effect (drug actions).  These drugs that we refer to can be a synthetic molecule or a bioactive from a natural source. Chrysanthemum indicum (Queen of East or Autumn Queen) is a perennial herbaceous botanical that belongs to the Asteraceae family.

Current gap in the literature associated with the bioactives of Chrysanthemum indicum:  There are no clear and specific studies that has elucidated the various bioactives and correlated its pharmacological effects for the prevention and treatment of various diseases.

Aims: Based on the current literature and the gap in the knowledge, we propose to elucidate the various bioactives of a Chrysanthemum indicum and furthermore by using the appropriate in-silico methods, the pharmacokinetic and pharmacodynamic effects will be elucidated.

Methods:  SwissADME, Uniport ID (Target Prediction Tool for protein targeting and their Kegg pathways) and DisGeNET (particular gene information).

Results and Conclusion: This Network Pharmacology concept of drug designing is the future of healthcare. Based on the Network Pharmacology concept, the bioactive of Chrysanthemum indicum has a multi-targeted and potent pharmacodynamic effect and thus it can be used to reduce animals and human ailments. 

Keywords: Chrysanthemum indicum, Network Pharmacology, Biological pathways, Biomolecules.