Curcumin is one of the most valuable natural bioactive owing to its prolific beneficial pharmacodynamic activities.  However, curcumin's extremely limited bioavailability has long been a barrier to its prophylactic and therapeutic applications in animal and human healthcare.  Notably, various metabolites of curcumin have become a relatively recent research topic of scientific interest, and extensive research has been accomplished to enhance curcumin usage. Furthermore, escalating scientific information shows that curcuminoid metabolites have biological activity comparable to or better than curcumin or its precursors.  However, there are very few studies on the effects of Tetrahydrocurcumin, a key curcumin metabolite, on the dopaminergic and hippocampal neurons. Hence, this study investigated the neuroprotective effects of Tetrahydrocurcumin.  In silico and in vitro studies were performed to elucidate the neuroprotective effects of Tetrahydrocurcumin. HT-22, the hippocampal cells, and N27, the dopaminergic neuronal cells, were used to establish the impact of Tetrahydrocurcumin on hippocampal and dopaminergic neuronal viability. Statistical analysis was accomplished using Prism-V software. Elucidating the in silico properties and neuroprotective mechanisms of Tetrahydrocurcumin can promote its prophylactic and therapeutic use in the treatment of various neurological diseases.