Healthy food habits have beneficial effects on physical and mental health. Food we eat determines the beneficial and detrimental effects on organs, especially - the gut and brain – via the immune system. This system mediates the responses that are generated from the enteric nervous system (ENS) and pass to the central nervous system (CNS) through the gut-brain axis. An ion-gated channel, alpha7 acetylcholine receptor, which is an essential part of the cholinergic anti-inflammatory mechanism, plays an important role in the regulation of inflammation in the gut and brain through vagus nerve. Vagus nerve upon electrical or chemical stimulation releases acetylcholine to activate α7AChR in macrophages, thereby modulating inflammation. As an example, we show that lipopolysaccharide-induced inflammation upregulates α7AChR and releases inflammatory molecule (TNFα) in macrophages. And the stimulation of α7AChR by its agonist, GTS-21, activates anti-inflammatory pathway and decreases increased levels of TNFα. We also show that binge alcohol consumption perturbs gut microbiome and transform commensal bacterial population into pathogenic and produces gut microbiome-derived metabolites, which are associated with the changes in behavior and brain function. Taken together, we suggest that coordination between ENS and CNS, mediated by immune system, is crucial to keep the gut and brain healthy. This coordination can be attained by making right choices of healthy and whole foods in the diet.